Analysis of the diagnostic value of procalcitonin in suppurative spondylitis
Objective To investigate the diagnostic value of procalcitonin(PCT)in pyogenic spondylitis(PS).Methods The results of PCT,C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)of 96 patients with pyogenic spondylitis(PS)(group A),91 patients with tuberculosis spondylitis(TBS)(group B)and 100 patients with osteoporotic vertebral compression fractures(OVCF)(group C)diagnosed in our hospital from January 2022 to December 2023 were collected.The sensitivity and specificity of the three indexes and their combination in the diagnosis of PS,TBS and OVCF were compared.The area under the ROC curve(AUC)was calculated to evaluate the diagnostic value of the three alone and in combination for pyogenic spondylitis.Results The age of onset in the group C was significantly older than that in the group A and B(P＜0.05),but there was no significant difference in the age of onset between the group A and the group B(P＞0.05).There were significant differences in the mean values of PCT,CRP and ESR among the three groups(P＜0.05),that was,the group A＞the group B＞the group C.The specificities of PCT,CRP and ESR in the group A were 77.5%,64.4%and 57.1%,respectively and 82.7%for combined diagnosis.The sensitivities of PCT,CRP and ESR in the group A were 80.2%,88.5%and 88.5%,respectively and 94.7%for combined diagnosis.The AUC of PCT,CRP and ESR in the group A were 0.820,0.720,and 0.779,respectively and 0.804 for combined diagnosis.All of them had diagnostic value(AUC＞0.5).Among them,PCT＞ESR,PCT＞CRP,and the combination of the three＞CRP(P＜0.05).There was no significant difference between ESR and CRP,PCT and the combination of the three,and ESR and the combination of the three(P＞0.05).The specificity of PCT,CRP and ESR in the group B was 59.2%,51.0%,49.0%,respectively and 75.2%for combined diagnosis.The sensitivities of PCT,CRP and ESR in the group B were 43.9%,62.6%,73.6%,respectively and 81.3%for combined diagnosis.The AUC of PCT,CRP and ESR in the group B were 0.740,0.664 and 0.624,respectively and 0.663 for combined diagnosis.All of them had diagnostic value(AUC＞0.5).Among them,PCT＞ESR,PCT＞CRP,and PCT＞the combination of the three(P＜0.05).There was no significant difference between ESR and CRP,the combination of the three and ESR,and the combination of the three and CRP(P＞0.05).Conclusions ① PCT,CRP,ESR and their combination have certain clinical value in the diagnosis of PS.The specificity of PCT and PCT combined with CRP and ESR in the diagnosis of PS is better than that of CRP and ESR.②PCT and PCT combined with CRP and ESR have high diagnostic efficacy for PS in the differential diagnosis of TBS and OVCF.
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