Analysis of the value of two CT perfusion software programs in assessing the ischemic core and penumbra in acute ischemic stroke
Objective To compare the agreement between two computed tomography perfusion(CTP)post-processing packages,Shukun and RAPID,for assessing ischemic core and penumbra volumes and to quantify the agreement between CTP predicted infarct volume and final infarct volume.Methods Clinical and imaging data of 73 patients with acute ischemic stroke were retrospectively collected.Final infarct volumes were measured by follow-up imaging 1～10 days after CTP imaging.Infarct core volumes and penumbra volumes were quantified using both Shukun and RAPID CTP post-processing software.Results In the 73 patients,the infarct volumes predicted by the two software packages were 36(84)ml and 34.3(87.2)ml,respectively,and the infarct volume on follow-up imaging was 46.71ml.The intraclass correlation coefficient(ICC)showed moderate to good consistency between the Shukun and the RAPID in predicting final infarct volume(Shukun:0.678 and RAPID:0.732).The correlation between the packages was also good(r=0.777).There was no statistically significant difference in the assessment of ischemic core volume between the two software packages(P＞0.05).There was also no statistically significant difference between RAPID predicted infarct volume and final infarct volume(P＞0.05).Conclusions The two perfusion post-processing software packages show good agreement in the quantitative assessment of infarct core and penumbra volumes.The Shukun post-processing software might be used as a well-established alternative to the RAPID.
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