Study on the correlation between extranodal extension of lymph nodes and clinicopathological characteristics as well as prognosis of patients with rectal cancer
Objective To observe the correlation between extranodal extension(ENE)of lymph nodes and clinicopathological characteristics as well as prognosis of rectal cancer patients.Methods A retrospective study was conducted on 132 rectal cancer patients with regional lymph node metastasis.The patients underwent radical surgery in our hospital between January 2019 and December 2021.Their clinicopathological data and follow-up information were collected.The ENE status was pathologically evaluated.The correlation between ENE and the clinicopathological characteristics as well as prognosis of the patients were analyzed.Results Among the132 patients,ENE was found in 63 cases(47.7%).Nerve invasion was more frequent and tumor budding grade,T staging,and N staging were higher in the ENE-positive group compared to the ENE-negative group(P＜0.05).The disease-free survival(DFS)rate was lower in the ENE-positive group(P＜0.05).However,there were no significant differences in gender,age,tumor location,histological grade,expression pattern of P53 protein,proliferation index of Ki-67 protein,and TNM staging between the two groups(P＞0.05).Conclusions The ENE positive status in rectal cancer indicates a more aggressive tumor.It is a negative prognostic factor and associated with poor survival outcomes.
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