初乳口腔免疫治疗对极低出生体重早产儿经口喂养能力及肠道菌群的影响
The effect of colostrum oral immunotherapy on oral feeding ability and gut microbiota in very low birth weight premature infants
高原 1张佳 1唐斌 1张军 1何龙兵 1李春杰2
作者信息
- 1. 江苏省宿迁市第一人民医院儿科,江苏 宿迁 223800
- 2. 江苏省苏州市儿童医院新生儿科,江苏 苏州 215000
- 折叠
摘要
目的 探讨初乳经口免疫疗法(C-OIT)在极低出生体重早产儿(VLBWI)支持治疗中的应用效果.方法 选择2021年4月至2023年3月江苏省宿迁市第一人民医院儿科收治的VLBWI 123 例,采用随机数字表法分为C-OIT组(n=62)、对照组(n=61).C-OIT组给予初乳口腔免疫治疗,对照组给予生理盐水口腔免疫治疗.治疗7d,比较两组早产儿经口喂养能力(PIOFRA)、肠道菌群、喂养效果、喂养并发症.结果 C-OIT组喂养前早产儿状态、吸吮能力、吞咽能力、喂养过程中维持生理稳定的能力、PIOFRA总分高于对照组(P＜0.05);乳酸杆菌、双歧杆菌高于对照组,大肠杆菌低于对照组(P＜0.05);开始经口喂养时间、完全经口喂养时间、恢复出生体重时间短于对照组(P＜0.05);喂养并发症 22.58%低于对照组 40.98%(χ2=4.809,P＜0.05).结论 C-OIT能够提高极低出生体重早产儿PIOFRA,调节肠道菌群,提高喂养效果,减少VLBWI喂养并发症的发生.
Abstract
Objective To investigate the effect of colostrum oral immunotherapy(C-OIT)in support development in very low birth weight premature infants(VLBWI).Methods One hundred and twenty-three VLBWI from April 2021 to March 2023 in Suqian First People's Hospital were selected.The infants were divided into a C-OIT group(n=62)and a control group(n=61)according the random number table method.The C-OIT group was given colostrum oral immunotherapy.The control group was given normal saline oral immunotherapy.The treatment course was 7 days.The Preterm Infant Oral Feeding Readiness Assessment(PIOFRA),intestinal flora,feeding effect and feeding complications were compared between the two groups.Results Thestate of premature infants before feeding,sucking ability,swallowing ability,the ability to maintain physiological stability during feeding,PIOFRA total score in the C-OIT group were higher than those in the control group(P＜0.05).Lactobacillus and Bifidobacterium in the C-OIT group were higher than those in the control group while Escherichia coli was lower than that in the control group(P＜0.05).The starting oral feeding time,complete oral feeding time and recovering birth weight time in the C-OIT group were shorter than those in the control group(P＜0.05).Feeding complications of the C-OIT group was 22.58%that was lower than 40.98%of the control group(χ2=4.809,P＜0.05).Conclusions C-OIT can improve the PIOFRA of VLBEI,regulate the intestinal flora,then improve the feeding effect and reduce the feeding complications.
关键词
极低出生体重早产儿/初乳口腔免疫治疗/早产儿经口喂养能力/肠道菌群Key words
Very low birth weight premature infants/Colostrum oral immune therapy/Preterm infant oral feeding readiness assessment/Intestinal flora引用本文复制引用
基金项目
江苏省妇幼健康科研项目(F201643)
宿迁市科技计划资助项目(SY202203)
出版年
2024
NETL
NSTL
万方数据