The effect of colostrum oral immunotherapy on oral feeding ability and gut microbiota in very low birth weight premature infants
Objective To investigate the effect of colostrum oral immunotherapy(C-OIT)in support development in very low birth weight premature infants(VLBWI).Methods One hundred and twenty-three VLBWI from April 2021 to March 2023 in Suqian First People's Hospital were selected.The infants were divided into a C-OIT group(n=62)and a control group(n=61)according the random number table method.The C-OIT group was given colostrum oral immunotherapy.The control group was given normal saline oral immunotherapy.The treatment course was 7 days.The Preterm Infant Oral Feeding Readiness Assessment(PIOFRA),intestinal flora,feeding effect and feeding complications were compared between the two groups.Results Thestate of premature infants before feeding,sucking ability,swallowing ability,the ability to maintain physiological stability during feeding,PIOFRA total score in the C-OIT group were higher than those in the control group(P＜0.05).Lactobacillus and Bifidobacterium in the C-OIT group were higher than those in the control group while Escherichia coli was lower than that in the control group(P＜0.05).The starting oral feeding time,complete oral feeding time and recovering birth weight time in the C-OIT group were shorter than those in the control group(P＜0.05).Feeding complications of the C-OIT group was 22.58%that was lower than 40.98%of the control group(χ2=4.809,P＜0.05).Conclusions C-OIT can improve the PIOFRA of VLBEI,regulate the intestinal flora,then improve the feeding effect and reduce the feeding complications.
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