Clinical study on the early prognosis of the systemic inflammatory response index in patients with sepsis
Objective To investigate the predictive value of the systemic inflammatory response index(SIRI)for sepsis patients'28-day mortality.Methods Clinical data of 150 sepsis patients admitted to the central ICU,emergency ICU and trauma ICU of the First Affiliated Hospital of Hainan Medical College from July 2019 to December 2022 were retrospectively analyzed.The SIRI was calculated.The patients were divided into a survival group and a death group according to the 28-day mortality.The clinical data were compared between the two groups.Multifactorial analysis was performed using the stepwise regression method,and the receiver operating characteristic curves(ROCs)were plotted.The predictive value of SIRI for sepsis prognosis was analyzed.Kaplan-Meier survival curves were plotted based on the cutoff values determined from the ROC curves.Results There were significant differences in white blood cell counts(WBC),neutrophil counts(NEU),monocyte counts(MON),activated partial thromboplastin time(APTT),lactate(LAC),oxygenation index(OI),acute physiology and chronic health assessment Ⅱ(APACHE Ⅱ)and sequential organ failure score(SOFA)and SIRI between the survival group and the death group(P＜0.05).The results of multifactorial logistic analysis showed that SIRI and APTT were independent risk factors for 28-day deaths in patients with sepsis.The results of ROC curve analysis showed that the areas under the curve of SIRI and APTT predicting the prognosis of patients with sepsis were 0.747 and 0.644,respec-tively,and the area under the curve of the combination of the two was 0.807.Survival analysis showed that the 28-day survival rate of patients with SIRI＞17.1×109/L was decreased with time.Conclusions SIRI helps in early prognostic assessment of sepsis patients.
NETL
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