Analysis of expressions of mutS homolog 2 and O6-methylguanine-DNA methyltransferase in patients with non-small cell lung cancer
Objective To explore the expressions of mutS homolog 2(MSH2)and O6-methylguanine-DNA methyltransferase(MGMT)in cancer tissues and their relationship with clinicopathological parameters and prognosis of patients with non-small cell lung cancer(NSCLC).Methods A total of 96 patients with NSCLC admitted to our hospital were enrolled between July 2021 and July 2022.NSCLC tissue specimens(NSCLC group)and normal para-carcinoma tissues which were 3 cm away from the cancer margin were collected(control group).The expression levels of MSH2 and MGMT in the two groups were detected,and their relationship with clinicopathological parameters and prognosis was analyzed.Results Compared with the control group,positive rates of MSH2 and MGMT were lower in the NSCLC group(P＜0.05).MSH2 was positively correlated with differentiation degree(P＜0.05),and MGMT was positively correlated with smoking history and differentiation degree(P＜0.05).The 1-year survival rate in patients with positive MSH2 and MGMT was higher than that in negative patients(P＜0.05).Conclusions The expressions of MSH2 and MGMT are down-regulated in NSCLC tissues.The two indexes are closely related to clinicopathological parameters and prognosis.
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