The role of dezocine in the improvement of perioperative neurocognitive dysfunction in elderly patients with fracturesby regulating oxidative stress levels
Objective To explore the effect of dezocine on perioperative neurocognitive disorders(PND)in elderly patients and its possible mechanism.Methods Sixty elderly patients with femoral fractures requiring surgical treatment were selected.The patients were divided into a dezocine group(Dez group)and a sodium chloride group(NS group)by using random number table method,30 in each group.Vital signs were recorded at the time of entry(T0)and at the end of operation(T1).The blocking plane was measured and the time from the plane to T10 and T8 were recorded.Peripheral venous blood was used to detect the expression levels of cortisol,C-reactive protein(CRP),superoxide dismutase(SOD)and malondialdehyde(MDA)at T0,T1 and 24 h(T2)after surgery.The perioperative neurocognitive disorders were assessed by using Simplified Mental State Assessment Scale before and after the 1st and the 7 th day of surgery.Results Compared with the NS group,the expressions of cortisol,CRP and SOD in the Dez group were increased while MDA expression was decreased at T1 and T2(P＜0.05).After 1 and 7 days of surgery,compared with group NS,the incidence of PND in the Dez group was lower(P＜0.05).MMSE score of the NS group was positively correlated with the expression levels of cortisol and SOD.Conclusions Dezocine can inhibit the oxidative stress level of postoperative elderly patients to a certain extent,thus alleviating PND.
NETL
NSTL
万方数据
