The effect of fondaparinux in the prevention of postoperative deep vein thrombosis in patients with osteosarcoma and its effect on coagulation function
Objective To explore the effect of fondaparinux in the prevention of postoperative deep vein thrombosis(DVT)in patients with osteosarcoma and its effect on coagulation function.Methods Ninety patients with osteosarcoma were divided into an ex-perimental group and a control group,45 in each group.Both groups began receiving anticoagulant treatment after 6-8 hours of surgery.The control group was treated with low molecular weight heparin calcium injection while the experimental group was treated with fondaparinux sodium injection.Both groups continued to take the medicines until 10-14 days after surgery.The incidence of DVT was compared between the two groups.The changes of the thromboplastin time(APTT),prothrombin time(PT),fibrinogen(FIB),D-dimer(D-D),white blood cell count(WBC),platelet count(PLT),alanine aminotransferase(ALT),aspartate amin-otransferase(AST)and serum creatinine(SCr)before and after treatment as well as the incidence of adverse bleeding reactions was compared between the two groups.Results There was no statistical difference in the incidence of DVT and APTT,FIB,D-D after treatment between two groups(P＞0.05).The PLT in the experimental group was significantly higher than that in the control group,and the SCr in the experimental group was significantly lower than that in the control group(P＜0.05).There was no statistical difference in the incidence of adverse bleeding reactions between the two groups(P＞0.05).Conclusions Both fondaparinux and low molecular weight heparin can effectively prevent the postoperative DVT in patients with osteosarcoma,and improve the coagulation function.However,fondaparine has less effect on PLT and renal function,and have a good clinical application prospect.
OsteosarcomaDeep vein thrombosisFondaparinuxLow molecular weight heparinCoagulation function
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