Research progress on nitric oxide in the treatment of acute respiratory distress syndrome
The main pathological features of acute respiratory distress syndrome(ARDS)are diffuse pulmonary interstitial and alveolar edema.It could lead to acute hypoxemic respiratory insufficiency or failure.As a therapeutic method with multiple biological and pharmacological effects,inhaled nitric oxide(iNO)plays an important role in the improvement of ventilation/blood flow ratio,the reduction of the pulmonary hypertension and the regulation of immune and inflammatory responses in patients with ARDS.Although iNO treatment failed to significantly improve the clinical prognosis of patients in previous clinical trials of ARDS,recent studies on ARDS phenotypes have emphasized its heterogeneity.This suggests that we need to further explore the differences in response to iNO treatment among different ARDS subtypes.In addition,further clinical research is needed on key issues such as the optimal starting time,duration,and therapeutic dose of iNO treatment in order to achieve better results in the treatment of ARDS patients.
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