Research status of neutrophil elastase in acute respiratory distress syndrome
Neutrophil elastase(NE)is the main protease in neutrophil azurophilic granules.It plays a crucial role in combating infections.However,excessive release of NE can trigger an amplified inflammatory response that can exacerbate pulmonary damage,leading to the onset of acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Sivelestat sodium is a specific neutrophil elastase inhibitor.It has obvious potential in the alleviation of neutrophil elastase induced pathological processes.The medicine has also garnered widespread attention in the clinical management of ARDS.This article will deeply explore the biological properties of NE and its mechanism of action in the pathophysiology of ARDS.The application of sivelestat sodium in the clinical man-agement of ARDS is also reviewed.Thus,the important clues for in-depth understanding of the mechanism of action of this drug in the treatment of ARDS would be provided.
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