中性粒细胞弹性蛋白酶在急性呼吸窘迫综合征中的研究现状
Research status of neutrophil elastase in acute respiratory distress syndrome
任佳佳 1李若寒 1金旭婷 1高晓明 1王岗1
作者信息
- 1. 西安交通大学第二附属医院重症医学科,陕西西安 710004
- 折叠
摘要
中性粒细胞弹性蛋白酶是中性粒细胞嗜天青颗粒中的主要蛋白酶,在抵御感染中发挥重要作用.然而,大量释放的中性粒细胞弹性蛋白酶可能导致过度炎症反应,加剧肺组织损伤,诱发急性肺损伤/急性呼吸窘迫综合征的发展.西维来司他钠作为一种特异性中性粒细胞弹性蛋白酶抑制剂,在缓解中性粒细胞弹性蛋白酶诱发的病理过程中具有明显的潜力,并在临床急性呼吸窘迫综合征的治疗中受到广泛的关注.本文将深入探讨中性粒细胞弹性蛋白酶的生物学特性及其在急性呼吸窘迫综合征病理生理中的作用机制,以及西维来司他钠在急性呼吸窘迫综合征临床管理中的应用,为深入理解该药物在急性呼吸窘迫综合征治疗中的作用机制提供重要线索.
Abstract
Neutrophil elastase(NE)is the main protease in neutrophil azurophilic granules.It plays a crucial role in combating infections.However,excessive release of NE can trigger an amplified inflammatory response that can exacerbate pulmonary damage,leading to the onset of acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Sivelestat sodium is a specific neutrophil elastase inhibitor.It has obvious potential in the alleviation of neutrophil elastase induced pathological processes.The medicine has also garnered widespread attention in the clinical management of ARDS.This article will deeply explore the biological properties of NE and its mechanism of action in the pathophysiology of ARDS.The application of sivelestat sodium in the clinical man-agement of ARDS is also reviewed.Thus,the important clues for in-depth understanding of the mechanism of action of this drug in the treatment of ARDS would be provided.
关键词
急性肺损伤/急性呼吸窘迫综合征/中性粒细胞弹性蛋白酶/凋亡/内皮损伤Key words
Acute lung injury/Acute respiratory distress syndrome/Neutrophil elastase/Apoptosis/Endothelial injury引用本文复制引用
出版年
2024
NETL
NSTL
万方数据