Study on the relationship between the levels of serum homocysteine,brain-derived neurotrophic factor and α-synuclein and the leukodystrophy in patients with Parkinson's disease
Objective To explore the relationship between the levels of serum homocysteine(Hcy),brain-derived neurotrophic factor(BDNF)and α-synuclein(α-Syn)and the leukodystrophy in patients with Parkinson's disease.Methods One hundred and four patients with Parkinson's disease admitted to our hospital from June 2022 to June 2023 were selected as an observation group.Meanwhile,60 healthy individuals who received physical examinations in the same time were selected as a control group.Clinical data of both groups were collected.Serum levels of Hcy,BDNF and α-Syn were measured.According to the severity of leukodystrophy,the patients in the observation group were further divided into a normal group,a mild lesion group,a moderate lesion group,and a severe lesion group.Clinical data and above-mentioned indicators of the four groups were compared.Multivariate logistic regression analysis was conducted to identify the influencing factors of leukodystrophy in patients with Parkinson's disease.The predictive value of biochemical indicators for leukodystrophy was analyzed using the receiver operating characteristic(ROC)curve analysis.Results The levels of serum Hcy and α-Syn were higher while BDNF level was lower in the observation group than those in the control group(P＜0.05).Patient age,course of disease,Hoehn-Yahr(HY)stages,Unified Parkinson's Disease Rating Scale(UPDRS)-Ⅲ scores,Hcy and α-Syn levels in the mild lesion group,the moderate lesion group and the severe lesion group were higher/larger than those in the normal group,while BDNF level was lower than that of the normal group(P＜0.05).Multivariate logistic regression analysis found that the levels of Hcy,BDNF and α-Syn were influencing factors of leukodystrophy in patients with Parkinson's disease(P＜0.05).ROC curve analysis showed that the AUC of α-Syn level for diagnosing leukodystrophy in patients with Parkinson's disease was the largest(0.949).Its sensitivity and specificity were 82.69％and 96.67％,respectively.The second was BDNF(0.829).The AUC of α-Syn was significantly larger than that of BDNF or Hcy(Z=2.832,4.991,P＜0.05).Conclusions Elevated Hcy and α-Syn are independent risk factors for leukodystrophy in patients with Parkinson's disease,while elevated BDNF is a protective factor.Hcy,α-Syn and BDNF can serve as biomarkers for leukodystrophy in patients with Parkinson's disease.
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