Study on the mechanism of the influence of ghrelin-obestatin on left atrial remodeling in patients with atrial fibrillation
Objective To investigate the regulatory effect of releasing peptide-obestatin system on inflammatory factors in patients with atrial fibrillation and its relationship with left atrial volume index.Methods Eighty-one patients with atrial fibrillation were selected as atrial fibrillation group.Another 80 healthy controls were selected as control group.Levels of serum ghrelin,obestatin,interleukin-18(IL-18),interleukin-6(IL-6)and C-reactive protein(CRP)were measured.Left atrial volume index(LAVI)was calculated by echocardiography in patients with atrial fibrillation.The correlation between the LAVI and the levels of ghrelin,obestatin,IL-18,IL-6 and CRP was analyzed.Results The expression levels of serum ghrelin,IL-18,IL-6 and CRP were higher while the expression level of obestatin was lower in the atrial fibrillation group than those in the control group(P＜0.05).In subgroup analysis,the expression levels of serum ghrelin,IL-18,IL-6 and CRP in patients with paroxysmal atrial fibrillation,persistent atrial fibrillation and permanent atrial fibrillation were sequentially increased(P＜0.05).The expression levels of obestatin in those subgroups were gradually decreased(P＜0.05).Spearman rank correlation analysis showed that the LAVI in the atrial fibrillation group was positively correlated with the levels of peripheral blood ghrelin,IL-18,IL-6,and CRP(all P＜0.01),while neg-atively correlated with obestatin levels(P＜0.01).Conclusions The expression of ghrelin,IL-18,IL-6 and CRP in the peripheral blood of patients with atrial fibrillation is increased,and the expression of obestatin is reduced.These are related to left atrial structural remodeling.The left atrial structural remodeling in patients with atrial fibrillation may be related to the regulation of inflammatory factors through the ghrelin-obestatin system.
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