Relationship between the levels of soluble programmed death ligand-1,chemokine ligand 9 and matrix metalloproteinase-9 in peripheral blood and the prognosis and survival in patients with non-small cell lung cancer
Objective To observe the correlation between the expression levels of soluble programmed death ligand 1(sPD-L1),chemokine ligand 9(CXCL9)and matrix metalloproteinase-9(MMP-9)in peripheral blood and the clinical characteristics as well as prognosis and survival in patients with non-small cell lung cancer(NSCLC).Methods Ninety-eight patients with NSCLC in our hospital were selected as a study group.Meanwhile,50 patients with benign pulmonary lesions were selected as a control group-1 and 50 healthy volunteers were selected as a control group-2.The expression levels of sPD-L1,CXCL9 and MMP-9 in peripheral blood of the three groups were compared.The prognosis and survival status in the study group after 1 year of treatment were followed up.The patients were further divided into a survival group and a death group.The predictive value of sPD-L1,CXCL9 and MMP-9 for prognosis and survival was analyzed using ROC curve analysis.Results The expression levels of sPD-L1,CXCL9 and MMP-9 in peripheral blood of the study group were higher than those in the control group-1 and control group-2,and the expression levels in the control group-1 were higher than those in the control group-2(P＜0.05).The expression levels of CXCL9 and MMP-9 in patients with TNM stage Ⅱ were higher than those in patients with stage Ⅰ.The expression levels of sPD-L1 and MMP-9 in patients with lymph node metastasis were higher than those in patients without metastasis(P＜0.05).TNM staging was positively correlated with CXCL9 and MMP-9 levels and lymph node metastasis was positively correlated with sPD-L1 and MMP-9 levels in patients with NSCLC(P＜0.05).The optimal cut-off values of sPD-L1,CXCL9 and MMP-9 for predicting the prognosis of NSCLC were 1.915 ng/ml,1.980 ng/ml and 179.030 μg/L,respectively.Moreover,the AUC and specificity of the three indicators jointly predicting the prognosis and survival of NSCLC patients were higher than those predicted by a single indicator(P＜0.05).Conclusions The expression levels of sPD-L1,CXCL9 and MMP-9 in peripheral blood of patients with NSCLC are up-regulated and closely related to clinical staging and lymph node metastasis.The combined detection of the three is of high value in predicting the prognosis of patients with NSCLC.
Non-small cell lung cancerSoluble programmed death ligand 1Chemokine ligand 9Matrix metalloproteinase 9Clinical characteristicPrognosis and survival
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