The effect of urinary kallidinogenase combined with butylphthalide on the expressions of neu-roglobin and cystatin C as well as neurological function in patients with acute progressive cerebral infarction
Objective To explore the effect of urinary kallidinogenase combined with butylphthalide on the neuroglobin and cystatin C as well as neurological function in patients with acute progressive cerebral infarction(APCI).Methods A total of 220 patients with APCI admitted to the First Affiliated Hospital of Nanyang Medical College from December 2020 to December 2021 were selected.The patients were divided into an observation group,a kallidinogenase group,a butylphthalide group and a control group according to random number table method,55 in each group.The control group received comprehensive symptomatic treatment.The butylphthalide group received comprehensive symptomatic treatment+intravenous infusion of butylphthalide.The kallidinogenase group received comprehensive symptomatic treatment+intravenous infusion of kallidinogenase.The observation group received comprehensive symptomatic treatment+butylphthalide+kallidinogenase.All four groups were treated continuously for 2 weeks.The clinical effects and the scores of serum cerebral globin,cystatin C and NIHSS before and after treatment were compared among the four groups.Results After treatment,cerebral globin in all groups was higher than before treatment while cystatin C and NIHSS scores were lower than those before treatment(P＜0.05).Serum cerebral globin level in the observation group was higher than that in the kallidinogenase group,the butylphthalide group and the control group while the cystatin C level and NIHSS scores in the observation group were lower than those in the kallidinogenase group,the butylphthal ide group and the control group(P＜0.05).There was no difference in the scores of cerebral globin,cystatin C and NIHSS between the kallidinogenase group and the butylphthalide group(P＞0.05).The total effective rate of the observation group was higher than that of the kallidinogenase group,the butylphthalide group and the control group(P＜0.05).Conclusions Urinary kallidinogenase combined with butylphthalide in the treatment of APCI can significantly increase the level of neuroglobin,reduce the level of cystatin C and NIHSS score and improve the neurological function of the patients and the clinical efficacy.It has certain clinical application value.
Urinary kallidinogenaseButylphthalideAcute progressive cerebral infarctionNeuroglobinCystatin C
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