Observation on the efficacy of ST ventilation mode with non-invasive ventilator combined with acetylcysteine aerosol inhalation in the treatment of patients with chronic obstructive pulmonary disease and type Ⅱ respiratory failure
Objective To observe the therapeutic effect of ST mode ventilation with non-invasive ventilator combined with ace-tylcysteine(NAC)aerosol inhalation in the treatment of patients with chronic obstructive pulmonary disease(COPD)and type Ⅱrespiratory failure.Methods A total of 120 patients with COPD and type Ⅱ respiratory failure admitted to our hospital from January 2018 to January 2023 were selected.The patients were divided into a conventional group(n=56)and a ST+NAC group(n=64)ac-cording to admission time.The conventional group received conventional treatment.The ST+NAC group received non-invasive ST ventilation mode combined with NAC atomization inhalation treatment.The clinical efficacy,serum superoxide dismutase(SOD),ma-londialdehyde(MDA),heart rate(HR),respiratory rate(RR),pulmonary function index,blood pH,arterial partial pressure of oxygen(PaO2)and arterial partial pressure of carbon dioxide(PaCO2)levels were compared before and after treatment between the two groups.Results The total effective rate of the ST+NAC group was higher than that of the conventional group(P＜0.05).After 7 days of treatment,SOD was increased and MDA was decreased in both groups,and the above indexes in the ST+NAC group were better than those in the conventional group(P＜0.05).After 7 days of treatment,the HR,RR,pH value,PaO2,PaCO2 and pulmonary function and blood gas related indexes in the two groups were better than those before treatment,and the above indexes in the ST+NAC group were better than those in the conventional group(P＜0.05).Conclusions ST ventilation mode combined with NAC aerosol in-halation in the treatment of COPD patients with type Ⅱ respiratory failure can improve the therapeutic effect and the ventilation function.It also inhibits the oxidative stress response of these patients.
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