Analysis of the efficacy of intrauterine infusion of platelet-rich plasma in patients with thin endometrium
Objective To investigate the effectiveness of intrauterine infusion of platelet-rich plasma(PRP)on pregnancy outcome in patients with thin endometrium who failed embryo transfer.Methods This was a prospective controlled trial.One hundred and twenty patients with thin endometrium who failed previous freeze-thawed embryo transfer(FET)cycles were selected.The patients were divided into a PRP group and a control group by using odd and even number lottery method,60 in each group.In addition to hormone replacement therapy(HRT),the PRP group received uterine perfusion PRP on days 8,10,and 13 of the FET cycle.The control group received HRT only.All subjects underwent three-dimensional energetic endometrial thickness,volume,mor-phology,and blood flow assays on the day of endometrial transformation.Differences in uterine 3D endometrial blood flow assay values and pregnancy outcomes were compared between the two groups.Results Endometrial thickness thickening,blood flow index(FI),embryo implantation rate,and clinical pregnancy rate on the day of endometrial transformation in the PRP group were significantly higher than those in the control group(P＜0.05).However,there was no significant differences in human chorionic gon-adotropin(HCG)positivity rate and early miscarriage rate between the two groups(P＞0.05).Conclusions Uterine perfusion of PRP can improve pregnancy rates in patients with thin endometrium.This is because that it can improve the uterine thickness and enrich the endometrial blood flow and increase the embryo implantation,thus,increasing the clinical pregnancy rates.
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