Relationship between the cerebrovascular load,serum neurofilament light chain and sodium levels and the short-term prognosis in patients with acute spontaneous cerebral hemorrhage
Objective To analyze the relationship between the cerebrovascular load,serum neurofilament light chain(NFL)and sodium levels and the short-term prognosis in patients with acute spontaneous intracerebral hemorrhage(sICH).Methods One hundred and twenty-nine patients with acute sICH admitted to our hospital were selected.The patients were divided into a good prognosis group and a poor prognosis group based on their 3-month modified Rankin Scale(mRS)scores.Clinical data,load score of cerebral small vessel disease(CSVD),serum NFL and sodium levels were compared between the two groups.The influencing factors of poor prognosis and the prognostic value of total burden score of CSVD,serum NFL and sodium levels in acute sICH were analyzed.Results The poor prognosis rate in this study was 35.66％.Compared with the good prognosis group,the proportion of massive cerebral hemorrhage,intracerebral hemorrhage(ICH)score at admission,total load score of CSVD and serum NFL level were higher in the poor prognosis group while serum sodium level and Glasgow Coma Scale(GCS)score were lower in the poor prognosis group(P＜0.05).GCS score,total load score of CSVD and serum NFL and sodium levels at admission were influencing factors of poor prognosis in patients with acute sICH(P＜0.05).The area under the ROC curve(AUC)values of the total load score of CSVD,serum NFL level and serum sodium level for predicting poor prognosis of acute sICH were 0.702,0.805 and 0.710,respectively.The AUC of combined prediction with the three was higher(0.906)(P＜0.05).Conclusions There is correlation between the total load score of CSVD,serum NFL and sodium levels and the short-term poor prognosis of patients with acute sICH.It may provide reference for prognosis evaluation of the disease.The predictive efficacy of combination of the three indices is higher.
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