The relationship between the serum high mobility group protein B1,platelet to lymphocyte ratio,nutritional status and the prognosis in patients with severe pneumonia
Objective To investigate the relationship between the serum high mobility group protein B1(HMGB1),platelet-to-lymphocyte ratio(PLR)and nutritional status and the prognosis in patients with severe pneumonia.Methods One hundred and fifty-six patients with pneumonia admitted to our hospital from March 2021 to March 2023 were selected.The patients were divided into a severe pneumonia group(n=75)and a common pneumonia group(n=81)according to clinical pulmonary infection score(CPIS).In addition,80 healthy people with physical examination in our hospital during the same period were taken as a control group.Patients with severe pneumonia were further classified into a good prognosis group(n=52)and a poor prognosis group(n=23)according to the disease outcomes after 30 days of follow-up.Serum HMGB1,PLR,nutritional status assessed by total protein(TP),transferrin(TRF)and hemoglobin(Hb)were compared among the groups.The relationship between serum HMGB1,PLR,nutritional status and Acute Physiology and Chronic Evaluation Ⅱ(APACHE Ⅱ)and CPIS in patients with severe pneumonia was analyzed.The factors affecting the prognosis in patients with severe pneumonia were also analyzed.Results Serum levels of HMGB1 and PLR in the severe pneumonia group and the common pneumonia group were higher than those in the control group while the levels of TP,TRF and Hb were lower than those in the control group(P＜0.05).The levels of serum HMGB1 and PLR in severe pneumonia group were higher than those in the common pneumonia group while the levels of TP,TRF and Hb were lower than those in the common pneumonia group(P＜0.05).Serum HMGB1 and PLR in the severe pneumonia group were positively correlated with the APACHE Ⅱ score and the CPIS score while serum TP,TRF and Hb levels were negatively correlated with the APACHE Ⅱ score and the CPIS score(P＜0.05).The levels of serum HMGB1 and PLR in the good prognosis group were lower while the levels of TP,TRF and Hb were higher compared with those in the poor prognosis group(P＜0.05).High levels of serum HMGB1 and PLR and low levels of TP,TRF and Hb were risk factors of prognosis in patients with severe pneumonia(P＜0.05).Conclusions Serum HMGB1 and PLR in patients with severe pneumonia show increasing trends while the levels of nutritional indicators TP,TRF and Hb show decreasing trends.The above indicators are significantly correlated with disease condition and prognosis of the patients.The higher serum HMGB1 and PLR,the lower the levels of nutritional indicators TP,TRF and Hb,and the worse the prognosis of the patients.
Severe pneumoniaSerum high mobility group protein B1Platelet-to-lymphocyte ratioNutritional statusProg-nosis
万方数据
维普
