Analysis of the therapeutic effect of medical peptide oral dressings combined with periodontal basic treatment for chronic periodontitis
Objective To explore the effects of medical polypeptide oral dressings combined with basic periodontal treatment for chronic periodontal disease.Methods One hundred and eight patients with chronic periodontal disease were selected.They were randomly divided into group A,B and C,36 in each group.All patients were treated with standardized periodontal basic treatment.In the group A,minocycline hydrochloride ointment was placed in the gingival sulcus.In the group B,iodoglycerin was placed in the gingival sulcus.In the group C,medical polypeptide oral dressingswere placed in the gingival sulcus.The course of treatment was 4 weeks.The total clinical effective rate,clinical periodontal parameters,inflammatory factors of gingival sulcus fluid and the incidence of adverse reactions were compared among the three groups.Results After treatment,the total clinical effective rate in the group C was higher than that in the groups A and B(P＜0.05).After treatment,the periodontal parameters such as probe depth(PD),clinical attachment level(CAL)and bleeding index(BI)of the three groups were lower than those before treatment(P＜0.05).There was no difference in PD and CAL among the three groups(P＞0.05)while BI of the group C was lower.After treatment,the concentrations of MMP-8 and TNF-α in gingival crevicular fluid in the group A were decreased(P＜0.05).After treatment,elastase and TNF-α in gingival crevicular fluid in the group B and C were decreased(P＜0.05).Conclusions The medical polypeptide oral dressings combined with basic periodontal treatment have a definite effect in patients with chronic periodontal disease.It can effectively improve the periodontal condition and promote the periodontal tissue healing.
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