Expression and clinical significance of three serum indicators in patients with non-small cell lung cancer
Objective To analyze the expression and clinical significance of serum glutathione S-transferase P1(GSTP1),fi-broblast growth factor receptor 1(FGFR1)and extracellular matrix metalloproteinase inducible factor(CD147)in patients with non-small cell lung cancer(NSCLC).Methods Ninety-six patients with NSCLC(NSCLC group)and 60 healthy individuals(control group)were included in this study.Serum GSTP1,FGFR1 and CD147 levels in the two groups,and in patients with different clinico-pathological characteristics were compared.The diagnostic efficacy of the three indicators for NSCLC was analyzed.Results The levels of serum GSTP1,FGFR1 and CD147 in the NSCLC group were higher than those in the control group(P＜0.05).There were statistical significance in the levels of serum GSTP1,FGFR1 and CD147 in NSCLC patients with different TNM stages and with/without lymph node metastasis(P＞0.05).The AUC,specificity and sensitivity of the combination of the three indicators for diagnosing NSCLC were 0.908,91.70％and 90.00％,respectively,which were higher than those with a single indicator(P＜0.05).Conclusions The levels of serum GSTP1,FGFR1 and CD147 are significantly elevated in patients with NSCLC.They affect the oc-currence,progression and prognosis of the disease.Joint detection of these indicators plays an important role in the clinical diagnosis and treatment of NSCLC.
万方数据
维普
