Objective To explore the causal relationship between frailty and chest pain discomfort by Mendelian randomization analysis using pooled data from a large-scale genome-wide association study.Methods A two-way Mendelian randomization study was used to investigate the causal relationship between frailty and chest pain discomfort.Weighted-median,MR-Egger,and IVW methods were used to estimate the causal relationship and assess its robustness.In addition,sensitivity analyses such as Cochran's Q test,MR-PRESSO,MR-Egger intercept test,and leave-one-out analyses were performed to improve the reliability of the findings.Results There was a bidirectional causal relationship between genetically predicted frailty and chest pain discomfort.Taking frailty as the exposure and chest pain discomfort as the outcome,there was a negative causal relationship between frailty and chest pain discomfort(OR=0.89,95％CI=0.88～0.90,P＜0.05).Taking chest pain discomfort as the exposure and frailty as the outcome,there was also a negative causal relationship between chest pain discomfort and frailty(OR=0.21,95％CI=0.12～0.35,P＜0.05).Conclusions This study confirms a bidirectional causal relationship between frailty and chest pain discomfort.As frailty increases,the risk of developing chest pain discomfort decreases.Conversely,as chest pain discomfort increases,the risk of developing frailty decreases.
维普
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