Analysis of the correlation between serum adiponectin,matrix metalloproteinase-9 and cognitive dysfunction in patients with acute stroke
Objective To analyze the correlation between serumadiponectin,matrix metalloproteinase-9(MMP-9)and cognitive dysfunction in patients with acute stroke.Methods One hundred and sixteen patients with acute stroke admitted to our hospital from May 2021 to February 2023 were selected as an observation group.Another 114 health people underwent physical examination in our hospital during the same period with normal physical examination indicators were selected as a control group.The observation group was further divided into groups with or without cognitive dysfunction and groups with different degrees of neurological impairment.The levels of serum adiponectin and MMP-9 were compared between the observation group and the control group,between the groups with and without cognitive dysfunction and between the groups with different degrees of neurological deficits.The correlation between serum adiponectin and MMP-9 and cognitive dysfunction in acute stroke patients was analyzed.Results Serum adiponectin levels were lower and MMP-9 levels were higher in the observation group than those in the control group(P＜0.05).Serum adiponectin levels were lower and MMP-9 levels were higher in the impaired group than those in the unimpaired group(P＜0.05).There were 31 cases in the mild injury group,37 cases in the moderate injury group,and 48 cases in the severe injury group.Comparison of serum adiponectin levels in patients with different degrees of neurological deficit in the observation group showed that the severe injury group＜the moderate injury group＜the mild injury group.Comparison of MMP-9 levels showed that the mild injury group＜the moderate injury group＜the severe injury group(P＜0.05).Pearson correlation analysis showed that serum adiponectin was positively correlated with Montreal Cognitive Assessment(MoCA)scores,and MMP-9 was negatively correlated with MoCA scores(P＜0.05).Conclusions Serum adiponectin and MMP-9 are closely associated with the onset and development of cognitive dysfunction in patients with acute stroke.Monitoring the levels above indicators can help to assess the degree of cognitive impairment and the prognosis of patients with acute stroke.
万方数据
维普
