Objective To explore the screening value of vestibular evoked myogenic potentials(VEMPs)examination for brain stem function injury in patients with early Parkinson's disease(PD).Methods A total of 106 patients with early PD and 100 healthy controls in our hospital were enrolled as a PD group and a control group,respectively.All subjects underwent VEMPs examination.VEMPs parameters were compared between the two groups.The diagnostic efficiency was analyzed.According to Parkinson's disease rating scale,the patients were divided into a good prognosis group and a poor prognosis group.VEMPs parameters in patients with different prognosis were compared,and their evaluation efficiency for prognosis was analyzed.Results The levels of p13,n23,n10 and p15 in the PD group were higher than those in the control group(P＜0.05).ROC curves analysis showed that AUC and cut-off values of p13 in the diagnosis of early PD were 0.806 and 15.56 ms,n23 were 0.773 and 24.54 ms,n10 were 0.817 and 12.39 ms and p15 were 0.620 and 15.47 ms.The AUC of combined detection was 0.945,that was greater than that of single index(P＜0.05).The levels of p13,n23,n10 and p15 in the good prognosis group were lower than those in the poor prognosis group(P＜0.05).ROC curves analysis showed that AUC and cut-off values of p13 for evaluating the prognosis of early PD were 0.824 and 19.36 ms,n23 were 0.803 and 27.36 ms,n10 were 0.775 and 13.28 ms and p15 were 0.789 and 17.19 ms.The AUC of combined detection was 0.975,that was greater than that of single index(P＜0.05).Conclusions VEMPs examination can better reflect early injury of brain stem function in PD patients.It has certain screening value and can evaluate the prognosis.
关键词
早期/帕金森病/前庭诱发肌源性电位/脑干功能损伤/筛查价值
Key words
Early stage/Parkinson's disease/Vestibular evoked myogenic potential/Brain stem function injury/Screening value
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