Study on the effect of pestle on serum inflammatory factors in patients with type 2 diabetic peripheral neuropathy
Objective To observe the effects of pestle needle intervention on serum inflammatory factors such as interleukin-1β(IL-1β),IL-6,and tumor necrosis factor-α(TNF-α)in patients with type 2 diabetic peripheral neuropathy(DPN).Methods Sixty-six DPN patients were divided into a control group and an experimental group by using random number table method.The control group received routine treatment and nursing care for DPN.The experimental group received clubbing needle therapy in addition to the routine treatment.The specific acupoints of clubbing needle therapy included Ming-men-ba-zhen,Zhi-yang-ba-zhen,He-che-ming-qiang section,Zu-san-li,San-yin-jiao,He-gu and Yang-ling-quan.The therapy was once a day,5 times a week for total of four weeks.The levels of serum inflammatory factors IL-1β,IL-6 and TNF-α,vibration sensation threshold(VPT),Clinical Symptom Score Scale(CSIT),and Toronto Clinical Neuropathy Scale(TCSS)scores before and after treatment were compared between the two groups.Results After treatment,there was a significant decrease in the levels of IL-1β,IL-6 and TNF-α as well as VPT,CSIT,and TCSS scores in both groups compared to before treatment(P＜0.05).Moreover,the levels of these indicators in the experimental group were significantly lower than those in the control group(P＜0.05).Conclusions Clubbing needle therapy can effectively reduce the levels of IL-1β,IL-6 and TNF-α as well as VPT,CSIT and TCSS in DPN patients by inhibiting inflammatory response.Thereby,it can improve the neurological function and clinical symptoms.
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