The effect of electronic bronchoscopy lavage therapy on clinical and laboratory indexes in patients with lobar pneumonia
Objective To explore the effect of electronic bronchoscopic lavage therapy on levels of interleukin(IL)-29 and e-osinophil(EOS)and serum high mobility group protein B-l(HMGB1)in patients with lobar pneumonia.Methods One hundred and four patients with lobar pneumonia treated in our hospital were selected.The patients were divided into a conventional group and a lavage group according to different treatment methods,52 in each group.The clinical indicators,and pulmonary ventilation function such as forced vital capacity(FVC),forced expiratory volume in one second(FEV1),maximum mid-expiratory flow(MMEF)and peak expiratory flow(PEF),blood gas indicators such as oxygen saturation(SaO2),partial pressure of oxygen(PaO2),oxygenation index(PaO2/FiO2)and partial pressure of carbon dioxide(PaCO2),IL-29,EOS count,serum inflammatory indicators such as HMGB1,tumor necrosis factor-α(TNF-α)and IL-6 as well as safety assessment before and after treatment were compared between the two groups.Results The symptom disappearance time and hospital stay in the lavage group were significantly shorter than those in the conventional group(P＜0.05).After treatment,the FVC,FEV,,PEF,MMEF,SaO2,PaO2and PaO2/FiO2in both groups were sig-nificantly increased(P＜0.05)while PaCO2 was declined(P＜0.05).After treatment,the IL-29 and EOS count in nasopharyngeal se-cretions and bronchoalveolar lavage fluid and levels of serum IL-6,TNF-α and HMGB1 of both groups were decreased(P＜0.05),and the indicators in the lavage group were lower compared with those in the conventional group(P＜0.05).There was no statistical difference in the occurrence of adverse reactions between the two groups.Conclusions Electronic bronchoscopic lavage therapy can ef-fectively improve the clinical symptoms,enhance the pulmonary respiratory function and blood oxygen saturation,and reduce the in-flammation level in patients with lobar pneumonia.It is more effective than traditional treatment regimen.
万方数据
维普
