The relationship between the levels of serum interleukin-17 and miRNA 424 and the clinico-pathological parameters and prognosis in patients with esophageal cancer
Objective To explore the expressions of serum interleukin-17(IL-17)and micro ribonucleic acid 424(miRNA 424)in patients with esophageal cancer(EC)and their relationship with clinicopathological parameters and prognosis.Methods Two hundred and twenty-four patients with EC in our hospital were selected.The general clinical data and pathological data of the patients were collected.The fasting venous blood of patients was collected after admission,and the levels of serum IL-17 and miRNA 424 were detected.The levels of serum IL-17 and miRNA 424 in EC patients with different pathological characteristics were compared.The rela-tionship between serum miRNA 424 levels and EC clinicopathological parameters was analyzed.The patients were followed up for 3 years after surgery.According to the survival status of patients,they were classified into a survival group(n=152)and a death group(n=71).The levels of serum IL-17 and miRNA 424 were compared between the two groups.Receiver operating characteristic(ROC)curve was adopted to analyze the predictive value of serum IL-17 and miRNA 424 levels for prognosis of EC patients.Results There were significant differences in the expressions of serum IL-17 and miRNA 424 in different ages,tumor diameter,TNM staging,differ-entiation degree,depth of invasion and lymph node metastasis(P＜0.05).The expression levels of serum IL-7 and miRNA 424 were significantly positively correlated with TNM staging,differentiation degree,depth of invasion and lymph node metastasis of EC(P＜0.05).The levels of IL-17 and miRNA 424 in the survival group were significantly lower than those in death group(P＜0.05).The sensitivities of IL-17 and miRNA 424 alone and in combination in the prediction of prognosis of EC patients were 77.46％,74.65％and 88.73％,and the specificities were 65.13％,62.50％and 61.84％,and the AUCs were 0.755,0.734 and 0.835,respectively.The combined diagnostic value was higher.Conclusions Serum IL-17 and miRNA 424 in EC patients are significantly correlated with clinical staging,differentiation degree,depth of invasion and lymph node metastasis.Both indicators have high diagnostic value on the prognosis of the patients.
万方数据
维普
