Observation on the effectiveness of different doses of nimodipine in preventing delayed cerebral vasospasm after subarachnoid hemorrhage
Objective To explore the effect of different doses of nimodipine in the prevention of delayed cerebral vasospasm(DCVS)after subarachnoid hemorrhage(SAH).Methods One hundred and seventeen patients with SAH admitted to the Department of Neurology of our hospital were included.The patients were divided into a low-dose group(n=57)and a high-dose group(n=60)according to different dosage regimens.The patient data were matched and scored to eliminate confounding factors.Finally,55 patients were obtained in each group.The efficacy(Hunt-Hess grading method),cerebral artery systolic peak velocity of middle cerebral artery(MCA),anterior cerebral artery(ACA)and posterior cerebral artery(PCA),peripheral blood indicators such as endothelin-1(ET-1),nitric oxide(NO)and copeptin,prognosis assessed by Glasgow outcome scale,occurrence of DCVS and cerebral infarction as well as adverse drug reactions were compared between the two groups.Results The total efficacy in the high-dose group was significantly better than that in the low-dose group(P＜0.05).After treatment,the cerebral artery systolic peak velocities of MCA,ACA and PCA in the two groups were significantly decreased(P＜0.05),and the velocities in the high-dose group were significantly lower than those in the low-dose group(P＜0.05).The level of ET-1 in both groups was reduced significantly after treatment,and the level in the high-dose group was significantly lower compared with that in the low-dose group(P＜0.05).The levels of NO and copeptin were significantly increased in both groups,and the high-dose group had significantly higher levels compared to the low-dose group(P＜0.05).The prognosis was significantly better in the high-dose group than that in the low-dose group(P＜0.05).The incidence of DCVS in the high-dose group was significantly lower than that in the low-dose group(P＜0.05).There was no statistical significance in the incidence of cerebral infarction between the two groups(P＞0.05).There was no statistical difference in the incidence of adverse drug reactions between the two groups(P＞0.05).Conclusions High-dose nimodipine has a good therapeutic effect.It can effectively relieve the cerebral nerve pressure,promote the blood circulation,and prevent the DCVS and cerebral infarction.It is worth promo-ting.
万方数据
维普
