Clinical application value of serum secreted phospholipase A2,soluble myeloid cell trigger re-ceptor-1 and macrophage inflammatory protein-3 a in pregnant patients with acquired community severe pneumonia
Clinical application value of serum secreted phospholipase A2,soluble myeloid cell trigger re-ceptor-1 and macrophage inflammatory protein-3 a in pregnant patients with acquired community severe pneumonia
Objective To explore the clinical application value of serum human secreted phospholipase A2(sPLA2),human soluble myeloid cell trigger receptor-1(sTREM-1)and macrophage inflammatory protein-3α(MIP-3α)in pregnancy patients with severe community acquired pneumonia(SCAP).Methods Eighty pregnant patients with SCAP admitted to our hospital from February 2019 to January 2023 were selected as a study group.During the same period,another 100 pregnant patients with non-severe community acquired pneumonia were selected as a control group.Serum levels of sPLA2,sTREM-1 and MIP-3α,Acute Physiology and Chronic Health Status Score System Ⅱ(APACHE-Ⅱ),pregnancy outcomes and neonatal outcomes were compared between the two groups.The relationship between serum levels of sPLA2,sTREM-1,MIP-3α and APACHE-Ⅱ score in pregnant patients with SCAP was analyzed by Spearman analysis.Multiple logistic regressions were used to analyze the factors affecting the neonatal outcome and de-velopment in pregnant patients with SCAP.Results The levels of serum sPLA2,sTREM-1 and MIP-3 as well as APACHE-Ⅱ score in the study group were significantly higher than those in the control group,and the incidence of maternal adverse pregnancy outcomes and the incidence of neonatal infection,asphyxia,sepsis,intrauterine distress,and neonatal pneumonia in the study group were higher than those in the control group(P＜0.05).Spearman analysis showed that the levels of sPLA2,sTREM-1 and MIP-3α were positively correlated with APACHE-Ⅱ score(P＜0.05).Multiple logistic regression analysis showed that high levels of sPLA2,sTREM-1,MIP-3α and elevated APACHE-Ⅱ scores were risk factors for adverse neonatal outcomes in pregnancy patients with SCAP(P＜0.05).ROC curve analysis indicated that sPLA2,sTREM-1 and MIP-3α could predict the adverse neonatal outcomes in pregnancy patients with SCAP.Among these indicators,sTREM-1 had the highest diagnostic efficiency(P＜0.05).Conclusions Serum sPLA2,sTREM-1 and MIP-3 α are closely related to the disease development of pregnant patients with SCAP.These indicators can effectively predict the neonatal outcome and development.Therefore,they can be applied in clinic practice.
Human secreted phospholipase A2/Human soluble myeloid cell trigger receptor-1/Macrophage inflammatory protein-3α/Pregnancy with severe community acquired pneumonia/APACHE-Ⅱ score/Neonatal outcome and development
维普
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