基于"肺与大肠相表里"理论探讨肠屏障损伤与慢性阻塞性肺疾病的关系
To Explore the Relationship Between Intestinal Barrier Damage and Chronic Obstructive Pulmonary Disease Based on the Theory of "Lung And Large Intestine Are External And Internal"
梁鹏涛 1仇振明 1宋丽云 1孙仪 1羊忠山1
作者信息
- 1. 云南中医药大学,云南 昆明 650000
- 折叠
摘要
在中西医不同的理论里,肺与大肠均存在密切的联系,在西医的理论里,肺与大肠在分化发育、生理病理、功能协作、物质联系上有结构、功能、菌群基础作为支撑依据,而这种联系与中医经典《黄帝内经》中所讲"肺与大肠相表里"不谋而合,在中医的"肺与大肠相表里"理论里肺与大肠通过经脉相络属,生理相协调以达到相互联系的目的,在汗牛充栋的历代医案中,也不乏肺病从肠论治,肠病从肺论治的治疗策略,现代医学研究发现,肠屏障的损伤与慢性阻塞性肺疾病之间可相互影响彼此的疾病病理发展进程,其中微生物屏障(主要为肠道菌群)可能是将肺与大肠进行动态联系的重要活性基础,其调节方式主要通过肠道菌群代谢产物实现,如维生素、短链脂肪酸等,因此维持肠道菌群的动态平衡及修复受损的肠屏障可能成为慢性阻塞性肺疾病的一种潜在治疗策略.文章通过系统归纳总结梳理了目前国内外学者对于肺与大肠在肠屏障损伤与慢性阻塞性肺疾病之间的潜在联系及最新的研究进展,综述了有关于肺与大肠在分化发育、生理病理、功能协作及物质联系之间的相互关系,阐释肠屏障损伤与慢性阻塞性肺疾病之间相互影响的联系,以期对该理论有进一步的认识并为临床上对肺肠疾病的治疗提供新思路.
Abstract
In different theories of Chinese and western medicine,there is a close connection between the lungs and the large intestine.In the theory of western medicine,the lungs and the large intestine have a structure,function,and microbial communi-ty foundation as the supporting basis for differentiation and development,physiological and pathological changes,functional coop-eration,and material connections.This connection coincides with the traditional Chinese medicine classic"Huangdi Neijing"which states that"the lungs and the large intestine are external and internal",In the theory of"lung and large intestine are ex-ternal and internal"in traditional Chinese medicine,the lung and large intestine are connected through meridians and coordinated with physiology to achieve mutual connection.In the numerous medical records of previous dynasties,there are also treatment strategies for lung diseases from the intestine and intestinal diseases from the lungs.Modern medical research has shown that the damage to the intestinal barrier and chronic obstructive pulmonary disease can mutually affect each other's pathological develop-ment process,Among them,microbial barriers(mainly gut microbiota)may be an important active basis for dynamically con-necting the lungs and large intestine,and their regulation is mainly achieved through gut microbiota metabolites such as vitamins and short chain fatty acids.Therefore,maintaining the dynamic balance of gut microbiota and repairing damaged gut barriers may become a potential treatment strategy for chronic obstructive pulmonary disease in the future,this article systematically summari-zes and sorts out the potential connections and latest research progress between the lung and large intestine in intestinal barrier in-jury and chronic obstructive pulmonary disease by domestic and foreign scholars.It reviews the interrelationships between the dif-ferentiation and development,physiological pathology,functional cooperation,and material connections between the lung and large intestine,and explains the interrelationships between intestinal barrier injury and chronic obstructive pulmonary disease,In order to have a further understanding of this theory and provide new ideas for the clinical treatment of pulmonary and intestinal diseases.
关键词
肺与大肠相表里/肠屏障/慢性阻塞性肺疾病/肠道菌群/紧密连接Key words
lung and large intestine inside and outside/intestinal barrier/Chronic obstructive pulmonary disease/intestinal flora/tight junctio引用本文复制引用
基金项目
国家自然科学基金(81860646)
云南省中医联合专项重点项目(202101AZ070001-012)
云南省优秀青年科学基金(2019F1016)
出版年
2024
国家科技期刊平台
NSTL
万方数据