To Explore the Relationship Between Intestinal Barrier Damage and Chronic Obstructive Pulmonary Disease Based on the Theory of "Lung And Large Intestine Are External And Internal"
In different theories of Chinese and western medicine,there is a close connection between the lungs and the large intestine.In the theory of western medicine,the lungs and the large intestine have a structure,function,and microbial communi-ty foundation as the supporting basis for differentiation and development,physiological and pathological changes,functional coop-eration,and material connections.This connection coincides with the traditional Chinese medicine classic"Huangdi Neijing"which states that"the lungs and the large intestine are external and internal",In the theory of"lung and large intestine are ex-ternal and internal"in traditional Chinese medicine,the lung and large intestine are connected through meridians and coordinated with physiology to achieve mutual connection.In the numerous medical records of previous dynasties,there are also treatment strategies for lung diseases from the intestine and intestinal diseases from the lungs.Modern medical research has shown that the damage to the intestinal barrier and chronic obstructive pulmonary disease can mutually affect each other's pathological develop-ment process,Among them,microbial barriers(mainly gut microbiota)may be an important active basis for dynamically con-necting the lungs and large intestine,and their regulation is mainly achieved through gut microbiota metabolites such as vitamins and short chain fatty acids.Therefore,maintaining the dynamic balance of gut microbiota and repairing damaged gut barriers may become a potential treatment strategy for chronic obstructive pulmonary disease in the future,this article systematically summari-zes and sorts out the potential connections and latest research progress between the lung and large intestine in intestinal barrier in-jury and chronic obstructive pulmonary disease by domestic and foreign scholars.It reviews the interrelationships between the dif-ferentiation and development,physiological pathology,functional cooperation,and material connections between the lung and large intestine,and explains the interrelationships between intestinal barrier injury and chronic obstructive pulmonary disease,In order to have a further understanding of this theory and provide new ideas for the clinical treatment of pulmonary and intestinal diseases.
lung and large intestine inside and outsideintestinal barrierChronic obstructive pulmonary diseaseintestinal floratight junctio
NETL
NSTL
万方数据
