Research Progress on the Correlation of HPA Axis and Hippocampal BDNF with Depression and the Treatment of Bupleurum
With the rapid development of the modem era,depression has become a common disease of human beings,with depression,taciturn,slow thinking,sleep disorders as the main symptoms,serious self-harm,suicide.The pathogenesis of de-pression is complex,involving biological,social,psychological and many other factors.There are many kinds of western antide-pressant drugs,which have certain efficacy,but there are problems such as large adverse reactions,low compliance and easy re-currence,while the treatment of traditional Chinese medicine has remarkable efficacy.This study reviewed the correlations be-tween hypothalamus-pituitary-adrenal(HPA axis)and hippocamal brain-derived neurotrophic factor(BDNF)with depres-sion,and antidepressant effects Bupleurum and its classic compound exert through regulating HPA axis and hippocampal BDNF,so as to provide theoretical reference for clinical research and development of more traditional Chinese medicine treatment of de-pression.
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