Study on the Mechanism of Inhibition of Nerve Regeneration by Activating Rhoa Signaling Pathway Induced by Excitatory Amino Acid Toxicity in Ischemic Stroke
Glutamate as a neurotransmitter,plays an important role in signal transmission in the central nervous system.The release of a large number of neurotransmitters caused by ischemic stroke can cause excitatory amino acid toxicity,and the contin-uous depolarization of neurons can cause cytoskeleton damage and cause various neurological dysfunction.It is found that after the central nervous system is damaged,a large number of nerve regeneration inhibitory molecules will be secreted to activate the RhoA protein pathway,which will lead to the collapse of the growth cone and inhibit the regeneration of neurites.Intervening the collapse of growth cone,reducing neurite injury caused by excitatory amino acid toxicity and promoting neurite regeneration have become the focus of current research.In this paper,the mechanism of glutamate damaging neurites and promoting neurite regen-eration will be discussed in depth.
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