基于肝脾相关理论探讨胆汁酸代谢异常对代谢相关脂肪性肝病的影响
Exploring Impact of Abnormal Bile Acid Metabolism on Metabolism-Related Fatty Liver Disease Based on Liver-Spleen Related Theory
徐翠瑜 1张明香2
作者信息
- 1. 辽宁中医药大学,辽宁沈阳 110847
- 2. 沈阳市第九人民医院,辽宁沈阳 110024
- 折叠
摘要
代谢相关脂肪性肝病已成为临床常见慢性肝病,国内外研究表明,胆汁酸已被确定为参与糖脂代谢的重要信号分子,胆汁酸代谢异常和肠道菌群紊乱与非酒精性脂肪肝的疾病严重程度密切相关,这种病理机制与传统医学中肝脾损伤在代谢相关脂肪性肝病中的致病机制相符合.文章结合肝脾相关理论探讨胆汁酸代谢异常对代谢相关脂肪性肝病的影响,以期为中西医结合防治代谢相关脂肪性肝病提供新的参考.
Abstract
Metabolic fatty liver disease has become a common chronic liver disease.Domestic and international studies have shown that bile acid has been identified as an important signaling molecule involved in glycolipid metabolism,and abnormal bile acid metabolism and intestinal flora disorders are closely related to the disease severity of non-alcoholic fatty liver disease.Therefore,this paper discussed the effects of abnormal bile acid metabolism on metabolism-related fatty liver disease in the con-text of liver and spleen-related theories and provided a new reference for the prevention and treatment of metabolism-related fatty liver disease by combining traditional Chinese and western medicine.
关键词
肝脾相关/代谢相关脂肪性肝病/胆汁酸代谢/肠道菌群Key words
liver and spleen being related/metabolism-related fatty liver disease/bile acid metabolism/intestinal flora引用本文复制引用
基金项目
国家自然科学基金青年科学基金(81703933)
沈阳市科技计划公共卫生研发专项(沈科发[2022]4)
出版年
2024
国家科技期刊平台
NSTL
万方数据