Research Progress of Related Signaling Pathways in the Treatment of Diabetic Nephropathy with Traditional Chinese Medicine Compounds
Diabetic nephropathy(DN)is the second leading cause of end-stage renal disease(ESRD),after glomerular disease.The mortality rate and disability rate are high,which seriously threaten human health,and Western medicine treatment is relatively simple after entering the stage of end-stage renal disease.Therefore,it is of great significance to explore the devel-opment of TCM compounds intervention in DN.TCM compounds can achieve the prevention and treatment effect of diabetic ne-phropathy through multi-target and multi-path.In recent years,more and more studies have been conducted on the effect and mechanism of TCM intervention on diabetic nephropathy.However,the effect of TCM compounds on the signaling pathway of dia-betic nephropathy is less.In this paper,adenylate activated kinase(AMPK)/silent information regulator(Sirt1),non-recep-tor tyrosine protein kinase 2(JAK2)/signal transducer and activator of transcription protein 3(ST AT3),transforming growth factor-β1(TGF-β1)/signal transduction protein(Smads)signaling pathway,Notch signaling pathway,Wnt/β-catenin,phosphoinositol 3-kinase(PI3 K)-serine/threonine protein kinase(AKT)and other signaling pathways,to explain the effect of traditional Chinese medicine on diabetic nephropathy.In order to provide reference for the guidance of traditional Chinese medicine compounds prevention and treatment of DN.
Chinese medicine compounddiabetic nephropathysignaling pathwayresearch progress
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