Clinical Observation on Major Cardiovascular Disease Risk Factors of Type 2 Diabetes Mellitus by Strengthening the Spleen and Kidney,Eliminating Blood Stasis and Resolving Phlegm
Objective To study the intervention of strengthening the spleen and kidney,eliminating blood stasis and resolving phlegm on major cardiovascular disease risk factors in patients with type 2 diabetes mellitus.Methods In a randomized controlled trial,patients attending the Department of Endocrinology of Yinchuan Hospital of Traditional Chinese Medicine and meeting the inclusion criteria were randomly divided into 35 cases in the experimental group and 35 cases in the control group,and the two groups were given conventional treatments of lowering glucose,lowering blood pressure,lowering lipids,diet,and exercise,and the experimental group was given the Ruanhua dongmai capsule,which was based on the principle of strengthening the spleen and the kidneys and eliminating blood stasis and resolving phlegm.The observation period was 90 days,The changes of body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting plasma glucose(FPG),2-hour post-prandial plasma glucose(2 hPG),glycosylated hemoglobin(HbA1c),low-density lipoprotein(LDL),triglyceride(TC),total cholesterol(TG),hypersensitive C-reactive protein(hs-CRP),and urinary micro-albumin(UM A)were recorded before and after the treatments,and the efficacy of Chinese medicine evidence was compared between the two groups of patients.Result-s There was no shedding case in the 90-day treatment cycle.After treatment,the effective rate of TCM efficacy of the patients in the test group was significantly higher than that of the control group(P＜0.05).Compared with the control group,the blood pressure(SBP,DBP),blood glucose level(FPG,2hPG,HbA1c),and lipid level(LDL,TG,TC)of the patients in the test group decreased significantly(P＜0.05),and the inflammatory index(hs-CRP)of the test group decreased significantly(P＜0.05)compared to the control group,while the UMA of patients in the test group improved significantly compared with the con-trol(P＜0.05).There were no significant adverse reactions and no acute cardiovascular events in both groups during the trial period.Conclusion It was initially observed that the method of strengthening the spleen and benefiting the kidney,expelling blood stasis and resolving phlegm had a protective effect on the major cardiovascular disease risk factors of patients with type 2 di-abetes mellitus,which is worthy of clinical promotion and application.
strengthening the spleen and kidneyexpelling blood stasis and resolving phlegmtype 2 diabetes mellituscar-diovascular disease risk factors
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