The Effect of Prunella Vulgaris Preparation in the Treatment of Graves Disease:A Systematic Review
Objective To systematically evaluate the efficacy and safety of oral Prunella vulgaris preparation combined with western medicine in the treatment of Graves disease,in order to provide evidence-based basis for future clinical application.Methods The study comprehensively and systematically searched four Chinese databases:Chinese Academic Journal Full-text Database(CNKI),Chinese biomedical literature database(CBM),Wanfang Data,VIP and three English databases:PubMed,EM-BASE and Cochrane Library.The retrieval time was from the establishment of the database to August 2022.Cochrane systematic bias risk assessment tool was used to evaluate the quality of the included studies,and Revman 5.4.1 software was used to meta-analyze the outcome indicators.Results Eight randomized controlled trials with 784 patients were included.The experimental group was treated with oral Prunella vulgaris preparation combined with western medicine,and the control group was treated with western medicine.The results of meta-analysis showed that the total effective rate of oral Prunella vulgaris preparation combined with western medicine in improving thyroid function and autoantibody and reducing thyroid gland was higher than that in the con-trol group(RR=1.13,95％CI[1.10,1.26],P＜0.000 01),and could significantly improve the clinical symptoms of goiter(MD=-0.39,95％CI[-0.67,-0.11],P=0.006),Decreased serum FT3 level(MD=-1.76,95％CI[-3.10,-0.43],P=0.01)and serum FT4 level(MD=-3.89,95％CI[-6.79,-1.00],P=0.008),increased serum thyroid stimulating hor-mone(TSH)level(MD=0.45,95％CI[0.05,0.86],P=0.03),and improved goiter of thyroid gland(MD=-0.39,95％CI[-0.67,-0.11],P=0.006),The anterior posterior diameter of the left lobe(MD=-0.31,95％CI[-0.57,-0.06],P=0.02),the left and right meridians(MD=-0.24,95％CI[-0.32,-0.16],P＜0.000 01),the anterior posterior diameter of the right lobe(MD=-0.30,95％CI[-0.47,-0.13],P=0.000 4)and the right and left meridians(MD=-0.21,95％CI[-0.33,-0.10],P=0.000 4).Conclusion Prunella vulgaris preparation combined with western medicine has obvious advan-tages and safety in the overall curative effect,improving the clinical symptoms of goiter,improving the level of thyroid hormone and narrowing the thyroid gland.However,the conclusion still needs the support of follow-up large samples and high-quality literature.
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