感染后肠易激综合征肠屏障功能损伤的研究进展
Progress in the Study of Post-Infectious Irritable Bowel Syndrome Impairment of Intestinal Barrier Function
张扬雨 1谢璐安 1陈小霞 1黄适2
作者信息
- 1. 广西中医药大学,广西南宁 530001
- 2. 广西中医药大学附属瑞康医院,广西南宁 530000
- 折叠
摘要
肠易激综合征(irritable bowel syndrome,IBS)是常见的功能性胃肠病,具体的发病机制尚未能阐明.感染后肠易激综合征(post-infectious irritable bowel syndrome,PI-IBS)是其中的一个亚型.肠黏膜屏障由机械屏障、免疫屏障、化学屏障、生物屏障4个部分组成,在维持肠道稳态发挥至关重要的作用.肠黏膜屏障受损和许多疾病相关,而这一病理改变在PI-IBS中客观存在.肠屏障功能损伤机制与PI-IBS的关系有待进一步研究.文章主要从PI-IBS相关的屏障损伤的机制进行概述,为深入研究和可能的临床应用提供帮助.
Abstract
Irritable bowel syndrome(IBS)is a common functional gastrointestinal disorder,the exact pathogenesis of which has not yet been elucidated.Post-infectious irritable bowel syndrome(PI-IBS)is one of the subtypes.The intestinal mucosal barrier consists of four components:mechanical,immune,chemical and biological barriers,and plays a crucial role in maintaining intestinal homeostasis.Impairment of the intestinal mucosal barrier is associated with many diseases and this pathological altera-tion is objectively present in PI-IBS.The relationship between the mechanisms of impairment of intestinal barrier function and PI-IBS needs to be further investigated.This article provides an overview of the mechanisms of barrier impairment associated with PI-IBS to provide an insight into further research and possible clinical applications.
关键词
感染后肠易激综合征/肠屏障功能/肠黏膜通透性/机械屏障Key words
post-infectious irritable bowel syndrome/intestinal barrier function/intestinal permeability/mechanical barrier引用本文复制引用
基金项目
国家自然科学基金地区科学基金(82060845)
广西壮族自治区一流学科建设开放课题(2019XK167)
出版年
2024
国家科技期刊平台
NSTL
万方数据