Research Progress of Traditional Chinese and Western Medicine in Modeling Methods for Slow Transit Constipation Animal Models
The animal model of constipation plays a crucial role in the study of constipation mechanisms and the development of laxatives,with the selection of modeling methods being particularly crucial.By reviewing literature and summarizing common modeling methods for slow transit constipation in rodent models,this article introduced three aspects:drug[compound diphenoxy-late,loperamide,morphine,sucralfate,fecal microbiota transplantation,Dahuang(rhubarb),rhein,and senna extract],non drug(water restriction,low fiber diet),and common TCM syndrome modeling(Qi stagnation,damp-heat,excess heat,body fluid defi-ciency,Qi deficiency,Yang deficiency,Yin deficiency and blood deficiency).The results showed that compound diphenoxylate and loperamide were still commonly used in drug modeling and the methods were relatively mature,but there were issues with un-clear modeling dosage,duration and stability.The animal model of laxative colon induced by Dahuang(rhubarb)and rhein has a long modeling cycle,but it is in line with the current clinical treatment status and deserves further research.Non pharmacological modeling has a high risk of self limitation and is suitable for studying the impact of lifestyle habits on slow transit constipation.The traditional Chinese medicine syndrome modeling mainly adopts a composite model of"physical stimulation+drug interven-tion",but the dose-response indicators are subjective and cannot objectively evaluate the effectiveness of syndrome modeling.
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