myocardial fibrosis(MF)is a disease that shows excessive proliferation of cardiac fibroblasts and accumulation of extracellular matrix(ECM).It is a common pathological change in the course of several cardiovascular diseases.The manifesta-tions are myocardial remodeling and myocardial metabolic disorders,which eventually lead to heart failure and death.Astragalo-side Ⅳ has pharmacological effects of anti-inflammation,anti-oxidative stress,anti-apoptosis and improvement of myocardial ischemia reperfusion,and has good potential in the prevention and treatment of myocardial fibrosis.This article aims to review the mechanism of astragaloside Ⅳ in the prevention and treatment of myocardial fibrosis,and provide reference for the clinical treat-ment of myocardial fibrosis.
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