Research Progress on the Mechanism of Effective Components of Traditional Chinese Medicine in Treating Diabetes Nephropathy by Acting On Mirna
Diabetes nephropathy(DN)is one of the most serious microvascular complications of diabetes.At present,the first-line drugs for DN are mainly renin angiotensin system(RAS)inhibitors or angiotensin receptor blockers,but the effect is still not ideal.Exploring practical DN drugs is still a difficult and key point in medical treatment.Some studies have shown that in the process of the occurrence and development of DN,several factors act alone or jointly to mediate the gene expression of renal pathology.Among them,microRNA(miRNA),as the regulatory factor of gene expression,can affect the occurrence and develop-ment mechanism of DN independently or crosswise by acting on different signal pathways.In recent years,a large number of stud-ies have found that the effective ingredients of traditional Chinese medicine can reduce the damage of glomerular mesangial cells,glomerular podocytes and renal tubules by regulating the expression of miRNA,and achieve the effect of treating DN.Therefore,by reviewing the mechanism of regulating miRNA treatment of DN by traditional Chinese medicine in recent years,it aims to provide a new way for the basic research and clinical application of traditional Chinese medicine treatment of DN.
diabetic nephropathytraditional Chinese medicinemiRNA
NETL
NSTL
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