Analysis of the Mechanism of Chinese Medication Rule in Treating Coronary Heart Disease with Hyperlipidemia based on Data Mining
Objective To explore novel treatment approaches of traditional Chinese medicine for coronary heart disease com-bined with hyperlipidemia,and to study,analyze,and summarize the principles of traditional Chinese medicine in treating this condition.Methods Literature published before June 1,2022 in PubMed,China Biomedical Literature Service System,VIP,Wanfang,and CNKI databases was searched to identify relevant studies on traditional Chinese medicine clinical treatment of coro-nary heart disease combined with hyperlipidemia.Only literature verified by randomized controlled trials was considered clear and effective.The Traditional Chinese Medicine Inheritance Assistance Platform(V3.0)was utilized for drug frequency analysis,as-sociation analysis,and cluster analysis of the included prescriptions.Result The study included 85 prescriptions comprising 148 different medicinal ingredients.Salvia miltiorrhiza(Danshen),hawthorn(Shanzha),and Tuckaia were identified as high-fre-quency drugs;while salvia miltiorrhiza paired with tangerine peel(Chenpi)were among the commonly used drug combinations.Notably,strong associations were observed between Tuckaia or tangerine peel with salvia miltiorrhiza or hawthorn respectively.Ultimately,11 core drug pairs and 5 new candidate prescriptions for treating coronary heart disease complicated with hyperlipi-demia were identified.Conclusion Through analyzing high-frequency drugs classification efficacy and proposing new candidate prescriptions,it was found that promoting blood stasis tonifying deficiency regulating qi regulating water dampness are commonly used strategies in combination to enhance therapeutic effects for patients suffering from both coronary heart disease complicated with hyperlipidemia.This study provides theoretical support for the clinical application of traditional Chinese medicine in such ca-ses.
data miningcoronary heart diseasehyperlipidemiamedication lawtraditional Chinese medicine inheritance as-sistance platform
万方数据
