Research progress in the treatment of PBC with traditional Chinese and western medicine
Primary biliary cholangitis(PBC)is a chronic intrahepatic cholestasis disease.Its pathological mechanism is re-lated to the imbalance of T lymphocyte ratio(Th1/Th2),apoptosis of bile duct epithelial cells,and estrogen regulation of IL-12/JAK-STAT signal pathway.The drugs used to treat PBC mainly include ursodeoxycholic acid and beta drugs,but the side effects of long-term use are obvious;Compared with western medicine,traditional Chinese medicine is effective and safe in the treatment of PBC,which can be attributed to the category of"accumulation"and"jaundice"of traditional Chinese medicine.Single traditional Chinese medicine and its compound medicine have significant curative effects.Its treatment features are the"holistic view"of the unity of heaven and man,and the treatment based on time,place and person,Its main treatment methods include soothing the liver and strengthening the spleen,tonifying the kidney and nourishing blood;Clear heat and dry dampness,dispel jaundice and promote gallbladder;It can promote blood circulation,promote diuresis,remove blood stasis and detoxify,which can significantly improve the clinical treatment effect of PBC and improve the symptoms of skin itching,abdominal disten-sion and other symptoms of patients.Therefore,this article reviews the research on the treatment of PBC with traditional Chinese and western medicine in order to provide new ideas and theoretical basis for the clinical diagnosis and treatment of PBC.
Chinese medicineprimary biliary cholangitistreatmentpathological mechanism
万方数据
维普
