Effects of Acupuncture on Cognitive Function in Children with Cerebral Palsy Based on Pi3K/Akt Signaling Pathway Analysis
Objective To explore the effect of acupuncture on cognitive function in children with cerebral palsy based on PI3K/Akt signaling pathway analysis.Methods 67 children with cerebral palsy treated in he First Affiliated Hospital of Henan Universi-ty of Traditional Chinese Medicine from January 2021 to June 2023 were randomly divided into observation group(35 cases)and control group(32 cases).The control group was given routine rehabilitation training,and the observation group was treated with acupuncture.The clinical efficacy,gross motor function(GMFM)score,peabody fine Motor Development Scale(PDMS-FM)score,cerebral hemodynamic indexes and the changes of PI3K/Akt pathway in peripheral blood mononuclear cells were compared between the two groups.Results The total effective rate of observation group was significantly higher than that of control group(P＜0.05).After treatment,GMFM score,PDMS-FM score,WPPSI score and average cerebral hemodynamic blood flow velocity of the two groups were significantly higher than those before treatment(P＜0.05),and the indexes of the observation group were significantly higher than those of the control group(P＜0.05).After treatment,PI3K expression in peripheral blood mononuclear cells of the two groups was significantly increased compared with that before treatment(P＜0.05),and Akt expression was signif-icantly decreased compared with that before treatment(P＜0.05).After treatment,PI3K expression in peripheral blood mononu-clear cells of the observation group was significantly higher than that of the control group(P＜0.05),and Akt expression was sig-nificantly lower than that of the control group(P＜0.05).Conclusion Acupuncture can effectively improve the gross motor and fine motor functions of children with cerebral palsy,and improve their cognitive functions.The mechanism may be related to the activation of PI3K/Akt pathway and the corresponding neuroprotective effect,which is worthy of clinical promotion.
PI3K/Akt pathwayacupuncturecerebral palsycognitive function
万方数据
维普
