Analysis of the Therapeutic Effect of Ganshuang Granule Combined with Tenofovir on Chronic Hepatitis B Patients with Liver Fibrosis
Objective To analysis of the therapeutic effect of Ganshuang Granule combined with tenofovir on chronic hepatitis B patients with liver fibrosis.Methods 72 patients with chronic hepatitis B liver fibrosis admitted to the hospital from January 2020 to January 2022 were randomLy divided into the combined group and the conventional group according to the random num-ber table method,with 36 patients in each group.The routine group was treated with tenofovir,and the combined group was treated with Ganshuang Granule on the basis of the routine group.The treatment time of both groups was 16 weeks.The clinical efficacy,liver function indexes[total bilirubin(TBIL),glutamic oxaloacetic transaminase(AST)],liver cirrhosis indexes[hyaluronic acid(HA),laminin(LN)]and adverse reactions were compared between the two groups.Results After treatment,The clinical efficacy of the combined group was better(P＜0.05).The levels of AST and TBIL in the two groups were lower than before,the levels of AST and TBIL in the combined group were lower(P＜0.05).The levels of HA and LN in the two groups were lower than before(P＜0.05),and the levels of HA and LN in the combined group were lower(P＜0.05),the incidence of adverse reactions was 13.89％in the combined group and 11.11％in the conventional group.There was no significant difference between the two groups(P＞0.05).Conclusion Ganshuang granule combined with tenofovir is effective in the treatment of chronic hepatitis B pa-tients with liver fibrosis,improving liver function and alleviating cirrhosis.It is safe and reliable and worthy of promotion.
Ganshuang granulechronic hepatitis B liver fibrosisinterleukin-6tumor bad factor-αincidence of adverse reactions
万方数据
维普
