Study on the Therapeutic Effects of Self-Made Persicae Semen & Paeoniae Radix Alba & Panax Notoginseng powder on Melasma Model Mice
Objective To investigate the therapeutic effects and mechanism of self-made Persicae Semen & Paeoniae Radix Alba & Panax Notoginseng powder on melasma model mice.Methods 100 mice were randomly divided into blank group,model group,Persicae Semen low/high-dose group,Paeoniae Radix Alba low/high-dose group,Panax Notoginseng low/high-dose group,Persicae Semen & Paeoniae Radix Alba & Panax Notoginseng powder low/high-dose group,10 groups in total,10 mice in each group.Mice models of melasma were prepared by progesterone injection combined with UVA irradiation.Superoxide dis-mutase(SOD)activity,malondialdehyde(MDA),and tyrosinase(TYR)levels in skin and liver tissues were measured and dermatopathological observations were made.Results Compared with the model group,the activity of SOD in skin and liver tissue was significantly increased(P＜0.05 or P＜0.01),and the contents of MDA and TYR were significantly decreased(P＜0.05 or P＜0.01)in both low and high dose groups.The results of the skin pathology test showed that the melanocytes in the skin of mice were relieved and the number of melanocytes was significantly reduced(P＜0.05 or P＜0.01),and the high-dose group showed a certain synergistic effect compared with each single drug group.The epidermal keratinization and epithelial cell hyperplasia of mice were improved in the low and high-dose groups of peach kernel Paeonia Panax Notoginseng powder,and the skin fiber structure,hair follicles,sebaceous glands and inflammatory infiltration of subcutaneous tissue in the dermis were also significantly improved compared with the model group.Conclusion Self-made Persicae Semen & Paeoniae Radix Alba &Panax Notoginseng powder is effective in the treatment of melasma,which is related to improving the body's antioxidant capacity,inhibiting tyrosinase activity,and improving inflammation.
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