Based on Data Mining to Explore the Formulation Rules of Traditional Chinese Medicine of Multiple System Atrophy
Objective To explore the formulation rules of TCM of multiple system atrophy based on data mining technology.Method Using"multiple system atrophy"and"traditional Chinese medicine""Chinese medicine""Chinese herbal medicine"as key-words or subject terms,we retrieve literatures on the Chinese medicine treatment of multiple system atrophy collected by CNKI,Wanfang and VIP from the establishment of the database to April,2023.And Excel2019,SPSS Modeler18.0,Cytoscape 3.7.1 and Qrigin 2021 were used for Chinese medicine frequency analysis,property,taste and meridian analysis,association rules a-nalysis,and cluster analysis.Results A total of 84 prescriptions and 174 herbs were included.25 herbs were used more than 16 times,and the top five herbs were cornus,cooked rehmannia,astragalus membranaceus,poria cocos,and angelica sinensis,the efficacy classification was mainly tonic medicine.The medicinal properties were mainly warm,cold,and flat,and the medicinal tastes were mostly sweet,bitter,and pungent.The three meridians of liver,kidney and spleen were the most common;The asso-ciation rules showed that the common drug combinations were cornus-cinnamon-aconite,aconite-cinnamon-cornus,cornus-aconite-cooked rehmannia,cornus-yam-cooked rehmannia;Cluster analysis of high-frequency herbs was performed,and five good cluster combinations were obtained.Conclusion The visceral lesions of multiple system atrophy are mainly kidney,liv-er,and spleen,and the pathogenesis is based on deficiency,kidney deficiency and deficiency of qi and blood are common.The principle of treatment is tonifying deficiency and reinforing the foundation,and attention should be paid to tonifying kidney,re-plenishing essence,supplementing qi and nourishing blood.
multiple system atrophydata miningmedication ruletraditional chinese medicineclustering