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基于数据挖掘分析中药熏洗促进混合痔术后创面愈合用药规律

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目的 运用数据挖掘分析临床应用中药熏洗促进混合痔术后创面愈合的用药规律.方法 收集中国知网(CNKI)、万方数据知识服务平台(WanFang Data)、维普中文期刊服务平台(VIP)以及中国生物医学文献数据库(CBM)2001年1月1日-2022年12月31日收录的中药熏洗促进混合痔术后创面愈合的临床研究文献,构建数据库;统计药物使用频次、性味归经、功效类别,并对药物进行关联规则分析、聚类分析.结果 共筛选出251首有效处方,涉及中药186味,使用频次前10味中药分别为苦参、黄柏、五倍子、大黄、芒硝、蒲公英、冰片、金银花、马齿苋和地榆;药性以寒、温为主,药味以苦、辛为主,归经以肝经、肺经为主;关联规则分析发现高频核心药对组合为苦参-地榆,3味药组合为苦参-五倍子-黄柏,聚类分析发现8组具有关联性的药物组合.结论 中药熏洗促进混合痔术后创面愈合多以消肿生肌、清热燥湿、清热解毒、活血化瘀为治法遣方用药,可供临床参考.
Discussion on Medication Law of TCM Fumigating and Washing Promoting Wound Healing after Mixed hemorrhoid Based on Data Mining
Objective To explore the medication law of TCM fumigating and washing to promote wound healing after mixed hemorrhoid using data mining methods.Methods The clinical research literature of TCM fumigating and washing to promote wound healing after mixed hemorrhoid was collected from CNKI,VIP,Wanfang Data and CBM from January 1,2001 to December 31,2022.The frequency of drug use,properties and tastes and meridians and efficacy categories were counted.Association rule analysis and cluster analysis were performed for drugs.Results A total of 251 effective prescriptions were screened out,involving 186 types of Chinese materia medica and the top 10 types of high-frequency Chinese materia medica were Kushen(Sophorae Flavescentis Radix),Huangbai(Phellodendri Chinensis Cortex),Wubeizi(Galla Chinensis),Dahuang(Rhei Radix Et Rhizoma),Mangxiao(Natrii Sulfas),Pugongying(Taraxaci Herba),Bingpian(Borneolum Syntheticum),Jinyinhua(Lonicerae Japonicae Flos),Machijian(Portulacae Herba)and Diyu(Sanguisorbae Radix).The medicinal properties were mainly cold and warm,and the medicinal tastes was mainly bitter and spicy;the meridians were mainly liver meridian and stomach meridian and the correla-tion rule analysis found that the high-frequency core medicine pairs were Kushen(Sophorae Flavescentis Radix)-Diyu(San-guisorbae Radix),the combination of 3 types of Chinese materia medica was Kushen(Sophorae Flavescentis Radix)-Wubeizi(Galla Chinensis)-Huangbai(Phellodendri Chinensis Cortex).The results of cluster analysis showed that eight groups of drug combinations with correlation were found.Conclusion TCM fumigating and washing to promote wound healing after mixed hemor-rhoid surgery is mostly used the treatment methods of detumescenting and promoting granulation,clearing heat,reducing dryness and dissipating dampness,clearing heat and removing toxicity,activating blood circulation and reducing blood stasis,which can be used as a clinical reference.

data miningTCM fumigating and washingmixed hemorrhoid surgerywound healingmedication law

秦诗媛、于永铎

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辽宁中医药大学,辽宁沈阳 110847

辽宁中医药大学附属第二医院,辽宁沈阳 110034

数据挖掘 中药熏洗 混合痔术后 创面愈合 用药规律

辽宁省"兴辽英才计划"项目

XLYC2002002

2024

实用中医内科杂志
辽宁省中医药学会,中华中医药学会,辽宁省中医药研究院

实用中医内科杂志

影响因子:0.421
ISSN:1671-7813
年,卷(期):2024.38(6)
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