As the most common and severe diabetic microvascular complication in diabetic patients,diabetic nephropathy(DN)is complex and multifactorial,involving many pathways and mediators,and is characterized by specific renal morphology and function changes.Studying the DN mechanism is the most important goal for DN prevention.Renal aging is one of the impor-tant causes of DN.There are many factors affecting renal aging,among which the dysregulation of Wnt/β-catenin signaling pathway activation is related with the occurrence and development of DN,which is important for regulating mesangial cell senes-cence in high glucose environment.In recent years,some progress and advantages have been made in the regulation of diabetic nephropathy through TCM,but the specific cell biological mechanism for delaying the aging of renal mesangial cells is not clear.This paper further summarized the extracellular signaling pathway,the relationship between Wnt/β-catenin and high glucose and the relationship between Wnt/β-catenin and renal mesangial cells,and preliminarily summarized the molecular mechanism of the role of TCM in delaying the aging process of mesangial cells,hoping to help the clinical efficacy of TCM in DN.
维普
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