Objective To explore the national patent Chinese medicine compound for the treatment of essential hypertension,analyze its medication rules and provide inspiration for clinical drug selection.Methods Using hypertension and traditional Chi-nese medicine as search keywords,the authorized patents published on the China Patent Announcement website affiliated to the State Intellectual Property Office were sorted out,and the database was created by Microsoft Excel 2018 and the frequency of tra-ditional Chinese medicine was statistically analyzed.SPSS Statistic 26.0 and SPSS Modeler 18.0 were used to analyze the meridi-an tropism,association rules and cluster analysis of high-frequency Chinese medicines(frequency ≥20),and a complex network diagram was constructed.The core prescription was explored based on Cytoscape.Results A total of 178 patent compound pre-scriptions were screened and included,involving 427 kinds of Chinese drugs.There were 26 kinds of Chinese drugs with frequen-cy ≥20.The top three were Danshen(Salviae Miltiorrhizae Radix Et Rhizoma),Gegen(Puerariae Lobatae Radix)and Xiakucao(Prunellae Spica).The four properties of the drugs were mainly cold,warm and flat,and the five flavors were mainly sweet and bitter.The liver,spleen,heart and kidney meridians were the majority.In the analysis of association rules,Danshen(Salviae Milt-iorrhizae Radix Et Rhizoma)-Gegen(Puerariae Lobatae Radix),Danshen(Salviae Miltiorrhizae Radix Et Rhizoma)-Duzhong(Eucommiae Cortex),Gegen(Puerariae Lobatae Radix)-Duzhong(Eucommiae Cortex)and other drug pairs ranked high in sup-port;cluster analysis obtained 6 groups of Chinese drugs combination;the excavated new prescription drugs were composed of Danshen(Salviae Miltiorrhizae Radix Et Rhizoma),Gegen(Puerariae Lobatae Radix),Xiakucao(Prunellae Spica),Fuling(Po-ria),Chuanxiong(Chuanxiong Rhizoma),Gouteng(Uncariae Ramulus Cum Uncis)and Duzhong(Eucommiae Cortex).Conclu-sion The national patent traditional Chinese medicine compound in the treatment of essential hypertension mostly uses Danshen(Salviae Miltiorrhizae Radix Et Rhizoma),Gegen(Puerariae Lobatae Radix),Xiakucao(Prunellae Spica)and other Chinese drugs,regulating the compatibility according to syndrome differentiation.
维普
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