Exploring Relevant Mechanisms of Blood Flow Shear Force Regulation in Coronary Heart Disease Based on Principle of"Liver Receiving Qi from Heart and Transmitting to Spleen"
The theory of"the liver receiving Qi from heart and transmitting to spleen"includes the concept of treating liver and spleen together.Liver and spleen are in the middle Jiao,and can regulate the Qi movement of Zang-Fu organs,which is so-called"the Zang-Fu organs with Qi excess can restrict the corresponding organs and counter-restrict the organs which it can not restrict in the normal state",liver and spleen function imbalance can affect heart.Studies have shown that soothing liver,strengthening spleen and eliminating phlegm method can regulate the level of miR-155,up-regulate ABC A1 which is the main receptor of cholesterol transvascular endothelial transport,reduce cholesterol deposition and improve coronary blood flow,but the specific mechanism is still unclear.Recent studies have shown that integrin activation of the blood flow shear stress receptor initi-ates downstream gene transcription in the nucleus of miR-155.Based on the previous foundation and the research progress at home and abroad,it pays attention to the role of environmental factors and lifestyle on the formation of coronary heart disease,and puts forward that"liver depression and spleen deficiency,internal turbid phlegm"is an important pathogenesis of atherosclerosis,revealing the scientific connotation of the new strategy of heart disease prevention and treatment in the theory of storing image in the Internal Classic,and providing scientific basis for the prevention and treatment of coronary heart disease by traditional Chinese medicine from liver and spleen.
coronary heart diseaseatherosclerosisliver depression and spleen deficiencyintergrinmiR-155CE