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中医药调控肠易激综合征相关信号通路的研究

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肠易激综合征(irritable bowel syndrome,IBS)是临床上常见的肠道功能性紊乱的疾病,发病机制复杂,目前尚未十分明确,且发病率逐年上升,严重影响患者生存质量及工作效率。西医常规治疗手段以抗痉挛,止泻,抗抑郁等为主,但疗效欠佳,症状迁延难愈。中医药治疗疾病在辨证论治基础上,注重整体观念,标本同治。中医药可通过作用于信号通路治疗IBS,与西医治疗相比,中医药治疗具有多层次,多环节,多靶点的优势。文章通过查阅国内外文献,对近年来相关文献疏理,整理出NF-κB/AKT-STAT/TRPV1/5-HT/MAPK/MicroRNAs相关信号通路,期望为中医药治疗IBS提供新的思路。
Study on Regulation of Signal Pathway Related to Irritable Bowel Syndrome by Traditional Chinese Medicine
Irritable bowel syndrome(IBS)is a common disease of intestinal functional disorder in clinic,the pathogenesis is complex and has not been very clear at present,and the incidence of IBS is increasing year by year,which seriously affects the quality of life and work efficiency of patients.The routine treatment of western medicine is mainly antispasmodic,antidiarrhea,antidepressant and so on,but the curative effect is not good and the symptoms are difficult to heal.Traditional Chinese medicine in the treatment of diseases on the basis of dialectical treatment,pay attention to the overall concept,specimen treatment.A large number of studies have shown that traditional Chinese medicine can act on signal pathway to treat IBS.Compared with west-ern medicine,traditional Chinese medicine has the advantages of multi-level,multi-link and multi-target.By consulting the literature at home and abroad,the author collates the NF-κB/AKT-STAT/TRPV1/5-HT/MAPK/MicroRNAs related signal pathway in recent years,hoping to provide a new way of thinking for the treatment of IBS with traditional Chinese medi-cine.

traditional Chinese medicineirritable bowel syndromesignal pathwayresearch progress

陈小霞、黄适、谢璐安、张扬雨、潘震东

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广西中医药大学,广西南宁 530001

广西中医药大学附属瑞康医院,广西南宁 530001

中医药 肠易激综合征 信号通路 研究进展

2024

实用中医内科杂志
辽宁省中医药学会,中华中医药学会,辽宁省中医药研究院

实用中医内科杂志

影响因子:0.421
ISSN:1671-7813
年,卷(期):2024.38(9)